Fermentation In Cytoplasm? 9 Facts You Should Know

The process of fermentation involves breaking down sugar molecules into simpler compounds in order to release energy in the form of ATP. Let us explore more.

The cytoplasm of a cell is where fermentation occurs. Eukaryotic and prokaryotic cells employ the reaction of fermentation to extract energy from food when oxygen levels are low. The production of ATP during fermentation is lower than that during cellular respiration since oxygen is not utilised.

Fermentation comes in a variety of forms. One type happens when glucose is converted into ATP and lactic acid, a waste product.

Does fermentation occur in cytoplasm?

The metabolic process of fermentation involves the action of enzymes to cause chemical alterations in organic substrates. Let us see if fermentation occurs in cytoplasm or not.

Fermentation occurs in cytoplasm of both eukaryotic and prokaryotic cells. Only when oxidative phosphorylation is absent to support the glycolysis-based ATP synthesis does fermentation take place. Lactic acid, ethanol, carbon dioxide, etc. are substances that pyruvate is converted into during fermentation.

When does fermentation occur in cytoplasm?

A lot of process occurs in cytoplasm during the transformation of sugar in muscles, yeast, plants and certain bacteria. Let us see if fermentation occurs in cytoplasm or not.

Fermentation happens in cytoplasm when aerobic respiration is unavailable, thus NADH formed after glycolysis cannot be converted into NAD+. Without NAD+, cells cannot continue to undergo glycolysis, and ATP synthesis is halted. Cells reduce NADH back into NAD+, by undergoing fermentation.

Despite the lack of oxygen, energy can still be generated from glucose through fermentation, which is an anaerobic process.

How does fermentation occur in cytoplasm?

The energy-producing route in cells that involves the anaerobic breakdown of substances like glucose is referred to as fermentation. Let us see how it occurs in cytoplasm.

In the absence of oxygen, either Pyruvate formed after Glycolysis or its derivative acetaldehyde act as electron acceptor of NADH and forms NAD+, thus continues Glycolysis and produces ATP and other substances like lactic acid, ethanol and CO2 as byproduct. This is how the process of fermentation takes place.

Why does fermentation occur in cytoplasm?

The cytoplasm of the cell serves as the site of fermentation. Let us see why fermentation occurs in cytoplasm.

Fermentation occurs in the cytoplasm of the cell, because it contains large concentrations of the associated enzymes and glucose needed for the fermentation pathway. The cell wall encloses the cytoplasm, which may be a viscous liquid that fills each cell.

Does lactic acid fermentation occur in the cytoplasm?

A metabolic process called lactic acid fermentation turns glucose into the molecule lactate and cellular energy. Let us see if lactic acid fermentation takes place in cytoplasm.

Lactic acid fermentation occurs in the cytoplasm of both eukaryotic and prokaryotic cells when there is not enough oxygen present for aerobic respiration to continue. This form of fermentation is frequently used in mammalian red blood cells and skeletal muscles.

Lactic acid fermentation from Wikipedia

How and When lactic acid fermentation occurs?

Lactic acid fermentation occurs in cells that produce ATP in the absence of oxygen and glycolysis occurs as a result. Skeletal muscles undergo lactic acid fermentation. Pyruvate is transformed into lactic acid by lactate dehydrogenase when oxygen is insufficient.

All these processes causes lactic acid to build up and causes muscle tiredness.

Does alcoholic fermentation take place in cytoplasm?

The anaerobic conversion of fructose and glucose into ethanol and CO2 is known as alcoholic fermentation. Let us explore if alcoholic fermentation occurs in cytoplasm or not.

Alcoholic fermentation takes place in the yeast’s cytoplasm in the absence of oxygen (Sablayrolles, 2009; Stanbury et al., 2013). Glycolysis, another name for the process by which yeasts break down sugars to produce pyruvate molecules, is the precursor to alcoholic fermentation.

Alcoholic fermentation from Wikipedia

How and When Alcoholic fermentation occurs?

The process of alcoholic fermentation starts with the breakdown of sugars by yeasts into pyruvate molecules. Two molecules of pyruvic acid are produced by the glycolysis of one glucose molecule. The two pyruvic acid molecules are subsequently split into two molecules each of ethanol and 2CO2.

Does fermentation occur in prokaryotic cells?

Fermentation takes place in the absence of oxygen to form energy through pyruvate in the cytoplasm of cell. Let us see if fermentation occurs in prokaryotes or not.

Fermentation occurs in prokaryotic cells in the absence of oxygen. Mostly in some obligate bacteria and archea, it is the primary source of energy production. Numerous prokaryotes can breathe oxygen on occasion.

Accordingly, they can alternate between aerobic respiration and fermentation based on the oxygen level.

Does fermentation occur in eukaryotic cells?

Eukaryotic cells are the highly developed form of cells. Most of the reaction in the cell occurs in cytoplasm. Let us know about the occurrence of fermentation in cytoplasm.

Fermentation occurs in the cytoplasm of eukaryotic cell. Cellular respiration begins with the process of Glycolysis which form pyruvate and NADH. If there is a lack of oxygen this pyruvate dose not enter in Mitochondria but remains in cytoplasm and undergoes the process of fermentation to liberate energy.


A metabolic process called fermentation uses different enzymes to release energy from sugar or other organic substrates. This kind of metabolic reaction is anaerobic. Both prokaryotic and eukaryotic cells undergo fermentation events in the cytoplasm. There are mainly two types of fermentation seen that are lactic acid fermentation and Alcoholic fermentation both occurs in the cytoplasm.

Sadiqua Noor

Hi...I am Sadiqua Noor, done Postgraduation in Biotechnology, my area of interest is molecular biology and genetics, apart from these I have a keen interest in scientific article writing in simpler words so that the people from non-science backgrounds can also understand the beauty and gifts of science. I have 5 years of experience as a tutor. Let's connect through LinkedIn-https://www.linkedin.com/in/sadiqua-noor-705593225

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